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Updated: Jun 5, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic gastroenteritis associated with giant folds
Kenji Ishido1, Satoshi Tanabe, Katsuhiko Higuchi
1Department of Gastroenterology, Kitasato University East Hospital, Kanagawa, Japan. k.ishido@kitasato-u.ac.jp
Summary
Minocycline-induced eosinophilic gastroenteritis can cause gastric issues. Prompt diagnosis and treatment with anti-allergic agents like suplatast led to patient recovery.
Area of Science:
- Gastroenterology
- Pharmacology
- Allergy
Background:
- A 54-year-old male presented with right subcostal pain.
- Previous minocycline prescription for pruritus had resolved symptoms.
Observation:
- Giant folds in the gastric greater curvature and edematous mucosa in the lesser curvature were observed.
- Biopsy revealed significant eosinophilic infiltration without atypical cells.
- Blood tests indicated marked eosinophilia and elevated serum immunoglobulin E.
Findings:
- Clinical presentation suggested drug-induced eosinophilic gastroenteritis.
- Minocycline withdrawal alone did not resolve symptoms.
- Suplatast administration led to prompt improvement in symptoms and hematological values.
Implications:
- Highlights the potential for minocycline to induce eosinophilic gastroenteritis.
- Demonstrates the efficacy of suplatast in managing drug-induced eosinophilic gastroenteritis.
- Emphasizes the importance of considering drug-induced causes in eosinophilic gastrointestinal disorders.
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