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Updated: Jun 5, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Developing pathogen reduction technologies for RBC suspensions.

S J Wagner1

  • 1Blood Components Department, American Red Cross Holland Laboratory, Rockville, MD 20855, USA. wagners@usa.redcross.org

Vox Sanguinis
|December 24, 2010
PubMed
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This summary is machine-generated.

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Pathogen reduction in red blood cell (RBC) suspensions requires targeting nucleic acids. Flexible photosensitizers and nucleic acid alkylating agents with quenchers show promise for safe transfusion medicine applications.

Area of Science:

  • Transfusion Medicine
  • Blood Safety
  • Pathogen Inactivation

Background:

  • Red blood cell (RBC) suspensions require pathogen reduction to ensure transfusion safety.
  • Existing methods are evaluated for efficacy and preservation of RBC properties.

Purpose of the Study:

  • To review methodologies for pathogen reduction in RBCs that maintain RBC properties.
  • To identify promising approaches targeting nucleic acids for pathogen inactivation.

Main Methods:

  • Evaluation of flexible photosensitizers that target nucleic acids.
  • Assessment of nucleic acid alkylating agents used with extracellular quenchers to prevent RBC membrane damage.
  • In vitro studies demonstrating pathogen inactivation and RBC property maintenance.

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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Published on: December 7, 2012

Related Experiment Videos

Last Updated: Jun 5, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Main Results:

  • Methods targeting nucleic acids demonstrate robust pathogen inactivation.
  • Flexible photosensitizers and alkylating agents with quenchers preserve RBC properties.
  • In vitro studies confirm specificity for nucleic acids, avoiding off-target photochemistry or alkylation.

Conclusions:

  • Targeting nucleic acids is key for effective pathogen reduction in RBCs.
  • Flexible photosensitizers and alkylating agents with quenchers are viable candidates for pathogen reduction.
  • Further development, including scale-up, toxicology, and clinical trials, is necessary for clinical application in Transfusion Medicine.