Biogenesis of chromomycin A3 by Streptomyces griseus
1Biocatalysis Research Group, College of Pharmacy, University of Iowa, Iowa City 52242.
The Journal of Antibiotics
|July 1, 1990
Abstract:
The biosynthesis of chromomycin A3 was investigated using 13C-labeled acetates, methionine and glucose, and 13C,18O-labeled acetate. 13C NMR spectral analysis demonstrated that: Aglycone assembly occurs by combining at least two polyketide chains; three of nine oxygen atoms of the aglycone originate from acetate precursor oxygen atoms; carbon methylations on the aromatic ring at C-7, on the chromose B sugar, and two O-methylations appear to be carried out by S-adenosyl-methionine requiring methyl transferases; and glucose is the precursor for all the sugars.
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