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Related Experiment Video

Updated: Jun 5, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Striatal structure and function in mood disorders: a comprehensive review.

William R Marchand¹, Deborah Yurgelun-Todd

¹Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA. wmarchand@me.com

Bipolar Disorders

|December 24, 2010

Summary

This summary is machine-generated.

Striatal abnormalities are linked to mood disorders like bipolar disorder and unipolar depression. Research suggests potential differences in striatal activity between these conditions, requiring further investigation.

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Animal Models of Depression - Chronic Despair Model (CDM)

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Published on: September 8, 2021

Animal Models of Depression - Chronic Despair Model (CDM)

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Published on: September 23, 2021

Area of Science:

Neuroscience
Psychiatry
Neuroimaging

Background:

Striatal structure and function abnormalities are implicated in unipolar and bipolar disorders.
Recent functional imaging studies have significantly advanced this research area.

Purpose of the Study:

To provide a comprehensive and critical review of the literature on striatal function in mood disorders.
To integrate current findings on the role of the striatum in affective illnesses.

Main Methods:

A systematic review of 331 relevant articles was conducted.
The review focused on studies examining striatal structure and function in mood disorders.

Main Results:

Compelling evidence indicates functional abnormalities in the striatum and corticostriatal circuitry in affective illnesses.
Bipolar disorder shows associations with striatal hyperactivity, while unipolar illness may involve hypoactivation.
The precise role of these striatal aberrations as primary pathology or contributors to symptoms remains undetermined.

Conclusions:

Further research into striatal function is crucial for understanding the neurobiology of affective disorders.
Developing comprehensive neurobiological models of mood disorders necessitates continued investigation of the striatum.