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Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature

Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature

Published on: October 14, 2022

Amniotic membrane transplantation for Mooren's ulcer.

Nguyen D Ngan¹, Hoang T M Chau

¹Department of Ophthalmology, Vietnam Military Medical University, Hanoi, Vietnam.

Clinical & Experimental Ophthalmology

|December 24, 2010

Summary

Amniotic membrane transplantation effectively treated Mooren's ulcer in most patients, promoting rapid epithelial healing. This surgical approach offers a viable alternative when systemic immunosuppression is not an option.

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Area of Science:

Ophthalmology
Regenerative Medicine

Background:

Mooren's ulcer is a severe form of peripheral ulcerative keratitis.
Treatment options for Mooren's ulcer can be limited, especially in cases resistant to medical therapy or conjunctival resection.

Purpose of the Study:

To evaluate the efficacy of amniotic membrane transplantation in treating Mooren's ulcer.
To assess the outcomes of epithelial healing and visual acuity following the procedure.

Main Methods:

A prospective interventional case series involving 18 eyes of 14 patients with Mooren's ulcer.
Amniotic membrane grafts (single or multilayer) were applied to the ulcerated corneas.
Surgical techniques included overlay and freehand grafts tailored to the defect.

Main Results:

Successful epithelial healing was achieved in 16 out of 18 eyes after a single surgery, with a mean healing time of 12.4 days.
Two eyes required a second graft due to complications (subgraft hemorrhage, persistent epithelial defect).
Visual acuity stabilized in all eyes, with 10 eyes achieving 6/12 or better vision.

Conclusions:

Amniotic membrane transplantation is a potentially useful surgical treatment for selected Mooren's ulcer cases.
This method is particularly valuable when systemic immunosuppressive drugs are inaccessible or contraindicated.