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Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Phyllanthus niruri as a promising alternative treatment for nephrolithiasis
Mirian A Boim1, Ita P Heilberg, Nestor Schor
1Renal Division, Federal University of Sao Paulo, Unifesp, Sao Paulo, Brazil. mirian@nefro.epm.br
Summary
Phyllanthus niruri shows potential in preventing and treating urolithiasis by interfering with stone formation and aiding elimination. Further clinical trials are needed to confirm its therapeutic efficacy for kidney stones.
Area of Science:
- Urology
- Phytochemistry
- Nephrology
Background:
- Urolithiasis remains a significant clinical challenge with limited effective treatments.
- Phyllanthus niruri, a widely distributed plant, has been traditionally used for various ailments.
Purpose of the Study:
- To review experimental and clinical evidence on Phyllanthus niruri for urolithiasis prevention and treatment.
- To evaluate the mechanisms of action and clinical effects of Phyllanthus niruri.
Main Methods:
- Literature review of experimental (in vivo/in vitro) and clinical studies.
- Analysis of data on Phyllanthus niruri's effects on crystal aggregation, composition, and cell interactions.
- Assessment of clinical outcomes related to ureteral relaxation and stone elimination.
Main Results:
- Phyllanthus niruri interferes with multiple stages of urolithiasis, including crystal aggregation and interaction with renal tubular cells.
- Clinical benefits may include ureteral relaxation, facilitating stone expulsion and post-lithotripsy fragment clearance.
- No significant adverse effects were reported in renal, cardiovascular, neurological, or toxicological assessments.
Conclusions:
- Phyllanthus niruri demonstrates promising preventive and potentially therapeutic effects in urolithiasis.
- Further long-term randomized clinical trials are essential to validate its therapeutic role in managing kidney stones.
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