Related Experiment Video

Updated: Jun 5, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Sodium thiosulfate-based treatment in calcific uremic arteriolopathy: a consecutive case series

A R Sood1, L D Wazny, C B Raymond

  • 1University of Manitoba, Winnipeg, Manitoba, Canada. msood@sbgh.mb.ca

Clinical Nephrology
|December 24, 2010
PubMed

Insights

Sodium thiosulfate (STS) showed promise for treating calcific uremic arteriolopathy (CUA) in a small patient group. While four patients responded to STS treatment for CUA, three out of six patients died within one year.

Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Medicine

Background:

  • Calcific uremic arteriolopathy (CUA) is a rare, high-mortality complication in end-stage renal disease patients.
  • Sodium thiosulfate (STS) has shown potential benefits in case reports for CUA treatment.
  • This study evaluates STS response in CUA patients with a one-year follow-up.

Purpose of the Study:

  • To assess the efficacy of a sodium thiosulfate (STS)-based treatment for calcific uremic arteriolopathy (CUA).
  • To evaluate patient response to STS over a one-year period.
  • To identify factors influencing STS treatment outcomes in CUA.

Main Methods:

  • Retrospective case series of 6 consecutive CUA patients treated with STS (2006-2008).
  • STS responders defined by improvement in pain, wound size, or imaging.
  • Collected data on mortality, STS dosage, duration, adverse events, and cost.

Main Results:

  • Four out of six patients were classified as STS responders.
  • Two surviving responders showed improvement in all parameters within 4-6 weeks.
  • Mortality rate was 50% (3 out of 6 patients) within one year.

Conclusions:

  • An STS-based approach led to a response in 4 CUA patients, but overall one-year mortality remained high (50%).
  • Further prospective studies are necessary to differentiate STS responders from non-responders.
  • The findings highlight the need for more research into optimizing CUA treatment strategies.
Abstract

Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...