Related Experiment Video

Updated: Jun 5, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Interplay between p53-family, their regulators, and PARPs in DNA repair

S Emami1

  • 1Inserm UMR S938, centre de recherche Saint-Antoine, université Pierre-et-Marie-Curie (université Paris-6), 184, rue du faubourg-Saint-Antoine, 75571 Paris cedex 12, France. shahin.emami@inserm.fr

Clinics and Research in Hepatology and Gastroenterology
|December 24, 2010
PubMed

Insights

The p53 tumor suppressor gene is frequently altered in cancer. This review focuses on p53

Area of Science:

  • Molecular biology
  • Genetics
  • Cancer research

Background:

  • Abnormalities in the p53 tumor suppressor gene are common in human cancers.
  • The p53 protein is extensively studied due to its critical role in preventing cancer.
  • Over 55,500 scientific papers focus on p53, highlighting its significance.

Purpose of the Study:

  • To review the functions of the p53 protein specifically in DNA repair.
  • To highlight recent advancements in understanding the signaling pathways that regulate p53 activity.

Main Methods:

  • Literature review of scientific papers on p53 and DNA repair.
  • Analysis of signaling proteins that interact with p53, including PARPs and ubiquitination factors.

Main Results:

  • p53 plays a crucial role in DNA repair mechanisms.
  • Key regulatory proteins influencing p53 function in DNA repair have been identified.
  • Progress has been made in understanding the roles of PARPs, MDM2, CRM1, USP10, and 14-3-3σ in p53 signaling.

Conclusions:

  • The p53 protein is a central player in DNA repair pathways.
  • Understanding p53 signaling is vital for cancer research and therapeutic development.
  • Further research into p53-interacting proteins will elucidate its role in preventing neoplasia.

More Related Videos

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter07:53

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter

Published on: April 17, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

Related Concept Videos

DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview