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Updated: Jun 5, 2026
Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
[Validation of an improved Demons deformable registration algorithm and its application in re-contouring in 4D-CT]
Xin Zhen1, Ling-hong Zhou, Wen-ting Lu
1Southern Medical University, Guangzhou, China. zhenjimmy@hotmail.com
Objective:
To validate the efficiency and accuracy of an improved Demons deformable registration algorithm and evaluate its application in contour recontouring in 4D-CT.
Methods:
To increase the additional Demons force and reallocate the bilateral forces to accelerate convergent speed, we propose a novel energy function as the similarity measure, and utilize a BFGS method for optimization to avoid specifying the numbers of iteration. Mathematical transformed deformable CT images and home-made deformable phantom were used to validate the accuracy of the improved algorithm, and its effectiveness for contour recontouring was tested.
Results:
The improved algorithm showed a relatively high registration accuracy and speed when compared with the classic Demons algorithm and optical flow based method. Visual inspection of the positions and shapes of the deformed contours agreed well with the physician-drawn contours.
Conclusion:
Deformable registration is a key technique in 4D-CT, and this improved Demons algorithm for contour recontouring can significantly reduce the workload of the physicians. The registration accuracy of this method proves to be sufficient for clinical needs.
