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Structure of a hepatotoxic pentapeptide from the cyanobacterium Nodularia spumigena
A Sandström1, C Glemarec, J A Meriluoto
1Department of Bioorganic Chemistry, University of Uppsala, Sweden.
Abstract:
The structure of a hepatotoxic peptide from the cyanobacterium Nodularia spumigena was determined using 1D and 2D proton nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. The toxin was a cyclic pentapeptide (mol. wt 824.5) with the structure cyclo-(beta-methylisoAsp-Arg-Adda-isoGlu-N-methylde hydrobutyric acid) (Adda: 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid).