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Left ventricular systolic strain in chronic kidney disease and hemodialysis patients

Yen-Wen Liu1, Chi-Ting Su, Yao-Yi Huang

  • 1Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.

American Journal of Nephrology
|December 24, 2010
PubMed

Insights

Chronic kidney disease (CKD) impairs heart function, with worsening renal function leading to reduced systolic function. Maintenance hemodialysis patients showed better left ventricular systolic function than moderate-advanced CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Medical Imaging

Background:

  • The effects of chronic kidney disease (CKD) and hemodialysis on cardiac function require further elucidation.
  • Investigating the impact of varying CKD stages and hemodialysis on heart function is crucial for patient management.

Purpose of the Study:

  • To assess the influence of different stages of CKD and maintenance hemodialysis on left ventricular (LV) function.
  • To quantify changes in systolic function using 2D strain analysis in CKD patients.

Main Methods:

  • Echocardiography and 2D speckle-tracking strain analysis were used to evaluate LV function in 153 patients.
  • Patients were stratified into three groups: controls (no CKD), moderate-advanced CKD (stages 3-5), and end-stage renal disease (ESRD) on maintenance hemodialysis.

Main Results:

  • No significant differences in gender, age, or LV ejection fraction were observed across groups.
  • Global peak systolic longitudinal strain (GS(l)), circumferential strain, and strain rate decreased in CKD patients compared to controls, worsening with renal function decline.
  • ESRD patients on maintenance hemodialysis exhibited better GS(l), circumferential strain, and strain rate than moderate-advanced CKD patients.

Conclusions:

  • Declining renal function is linked to reduced systolic function, quantifiable by 2D strain analysis.
  • Maintenance hemodialysis appears to preserve or improve LV systolic function compared to moderate-advanced CKD.
Abstract

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