Plasma fibronectin level in patients with functional thyroid adenoma

1. Plasma fibronectin level may serve as a sensitive, but not specific marker of thyroid hormone effect at peripheral, connective tissue level. 2. In some patients with preclinical hyperthyroidism an inverse relationship is detected between pFn and serum TSH reflecting an excessive effect of thyroid hormones at the target organ level. This finding suggests that suppressed TSH secretion might be deleterious in the long-term, which may have therapeutical implications.