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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Atypical Pneumonia01:14

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Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source
06:37

Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source

Published on: February 7, 2013

Human origin for avian pathogenic Staphylococcus aureus.

Bethan V Lowder1, J Ross Fitzgerald

  • 1The Roslin Institute and Centre for Infectious Diseases, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK.

Virulence
|December 24, 2010
PubMed
Summary
This summary is machine-generated.

A common Staphylococcus aureus (S. aureus) clone causing poultry infections originated from a single human-to-poultry host jump. This event led to genetic changes and global spread, highlighting risks of pathogen transmission.

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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

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Last Updated: Jun 5, 2026

Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source
06:37

Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source

Published on: February 7, 2013

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Veterinary Medicine

Background:

  • Staphylococcus aureus is a significant human and livestock pathogen.
  • The evolutionary history and cross-species transmission of S. aureus strains, particularly in animals, are poorly understood.
  • Understanding these origins is crucial for controlling infections in both humans and agriculture.

Purpose of the Study:

  • To investigate the evolutionary origin of a prevalent Staphylococcus aureus clone responsible for infections in the global broiler poultry industry.
  • To provide evidence for a specific host jump event and subsequent genetic diversification.
  • To discuss the implications of this event for pathogen evolution and interspecies transmission.

Main Methods:

  • Phylogenetic analysis of S. aureus isolates from poultry.
  • Genomic sequencing to identify genetic modifications and mobile genetic elements.
  • Comparative genomics to trace evolutionary pathways and virulence gene evolution.

Main Results:

  • Evidence suggests a single human-to-poultry host jump event initiated the poultry S. aureus clone.
  • The clone underwent significant genetic diversification post-transfer, including the acquisition of mobile genetic elements and loss of virulence genes.
  • The clone has spread globally within the poultry industry, facilitated by international trade.

Conclusions:

  • The study demonstrates a clear example of S. aureus cross-species transmission from humans to poultry.
  • Genetic adaptation and diversification enabled the successful establishment and spread of the clone in a new host.
  • This highlights the potential for other S. aureus strains to transfer between species and the importance of monitoring such events.