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Updated: Jun 5, 2026
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
IL-17 in protective immunity to intracellular pathogens
Shabaana A Khader1, Radha Gopal
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Shabaana.Khader@chp.edu
Virulence
|December 24, 2010
Summary
The interleukin-23 (IL-23) and T helper 17 (Th17) cell pathway is crucial for immunity against intracellular pathogens. This pathway regulates innate and adaptive immune responses, challenging earlier beliefs about its necessity.
Area of Science:
- Immunology
- Microbiology
- Cellular Biology
Background:
- T helper 17 (Th17) cells are known for immunity against extracellular bacteria.
- Initial research indicated the IL-23-IL-17 pathway was not vital for defense against intracellular pathogens like mycobacteria.
Purpose of the Study:
- To discuss the evolving understanding of the IL-23-IL-17 pathway's role in protective immunity.
- To explore its function in regulating immune responses against intracellular pathogens.
Main Methods:
- Literature review and synthesis of recent studies.
- Analysis of the regulatory mechanisms of the IL-23-IL-17 pathway in immunity.
Main Results:
- Recent findings suggest the IL-23-IL-17 pathway is crucial for immunity against various intracellular pathogens.
- This pathway modulates both innate and adaptive immune responses.
Conclusions:
- The role of the IL-23-IL-17 pathway in protective immunity against intracellular pathogens is more significant than previously thought.
- Further research is warranted to fully elucidate its mechanisms.
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