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High-dose cytosine arabinoside-induced symptomatic bradycardia

Siddharth A Wayangankar1, Bhavin C Patel, Hiral D Parekh

  • 1aDepartment of Internal Medicine bSection of Hematology and Oncology cSection of Cardiovascular Diseases, University of Oklahoma, Oklahoma City, Oklahoma, USA.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|December 24, 2010
PubMed

Insights

High-dose cytosine arabinoside (HiDAC) can cause rare cardiac issues. This case report confirms a definite adverse drug reaction linking cytarabine to symptomatic sinus bradycardia.

Area of Science:

  • Cardiology
  • Pharmacology
  • Oncology

Background:

  • High-dose cytosine arabinoside (HiDAC) is a chemotherapy agent.
  • Cardiac complications, though rare, are known adverse effects of HiDAC.
  • Arrhythmias are infrequently reported with HiDAC treatment.

Observation:

  • A case report details a patient experiencing symptomatic sinus bradycardia.
  • The Naranjo Scale was utilized to assess the adverse drug reaction.
  • Cytarabine was the suspected causative agent.

Findings:

  • A high-probability association was established between cytarabine and symptomatic sinus bradycardia.
  • This represents a definite adverse drug reaction.
  • The Naranjo Scale confirmed the link with high confidence.

Implications:

  • Highlights a rare but significant cardiac complication of cytarabine therapy.
  • Emphasizes the importance of monitoring cardiac function during HiDAC treatment.
  • Contributes to understanding the કાર્ડियोভাসকুলर toxicity profile of cytarabine.

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