Contemporary clinical applications of spatio-temporal image correlation in prenatal diagnosis

Four-dimensional fetal echocardiography has the potential to reduce the operator dependency of two-dimensional ultrasonography and increase the detection rate of congenital heart defects (CHDs). This review is intended to summarize recent evidence of the important role that four-dimensional ultrasonography with spatio-temporal image correlation (STIC) may play in the prenatal diagnosis of CHDs.

Four-dimensional ultrasonography with STIC may provide the opportunity for telemedicine in the prenatal diagnosis of CHDs because four-dimensional volume datasets can be remotely acquired and accurately interpreted by different centers. Four-dimensional ultrasonography with STIC is an accurate and reproducible technique for the prenatal diagnosis of CHDs. Different four-dimensional rendering techniques can provide important insight into the spatial relationships of normal and abnormal fetal vascular structures.

Four-dimensional fetal echocardiography with STIC may facilitate the examination of the fetal heart and could potentially increase the detection rate of CHDs.