Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic susceptibility shaped by biological state: beyond gene-environment interaction.

Frontiers in genetics·2026
Same author

Heart failure hospitalization in patients with and without type 2 diabetes: A population-based retrospective cohort study.

PloS one·2026
Same author

HFpEF risk assessment using H<sub>2</sub>FPEF score in community-dwelling young Hispanic adults.

Frontiers in cardiovascular medicine·2026
Same author

Associations Between Metabolic Dysregulation and Stage B Heart Failure in Hispanic Populations.

Echocardiography (Mount Kisco, N.Y.)·2026
Same author

SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencing.

Nature communications·2026
Same author

Integrated Genomic and Transcriptomic Study Reveals <i>MAPK11</i> and <i>PER1</i> as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population.

Circulation. Genomic and precision medicine·2026

Related Experiment Video

Updated: Jun 5, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Knowledge gaining by human genetic studies on tuberculosis susceptibility.

Hui-Qi Qu1, Susan P Fisher-Hoch, Joseph B McCormick

  • 1Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Brownsville, Texas 78520, USA. Huiqi.Qu@uth.tmc.edu

Journal of Human Genetics
|December 24, 2010
PubMed
Summary

Genetic studies reveal new insights into tuberculosis (TB) susceptibility. Genome-wide association studies (GWAS) challenge traditional views, identifying novel genetic loci unrelated to Mycobacterium tuberculosis (MTB) infection.

More Related Videos

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

  • Genetics
  • Infectious Diseases
  • Genomics

Background:

  • Tuberculosis (TB) poses a significant global health challenge, particularly in developing nations.
  • Understanding the genetic underpinnings of TB is crucial for developing effective prevention and treatment strategies.
  • Previous genetic research relied heavily on linkage mapping and candidate-gene association studies.

Purpose of the Study:

  • To investigate the genetic basis of tuberculosis susceptibility using a genome-wide approach.
  • To identify novel genetic loci associated with active TB.
  • To challenge existing hypotheses regarding TB genetic susceptibility.

Main Methods:

  • Genome-Wide Association Study (GWAS) was employed as a primary hypothesis-free method.
  • Analysis of genetic loci associated with active TB.
  • Comparison of GWAS findings with previously identified candidate genes.

Main Results:

  • The first GWAS on TB provided proof-of-principle for the genetic approach.
  • No previously known candidate genes involved in controlling Mycobacterium tuberculosis (MTB) infection were associated with active TB.
  • TB-associated loci identified by GWAS did not harbor genes with known functions in MTB infection.

Conclusions:

  • Genome-wide association studies offer a powerful, hypothesis-free approach to uncover novel genetic factors in TB.
  • Current understanding of TB genetic susceptibility may need re-evaluation, as identified loci are not linked to known MTB infection pathways.
  • Further research is warranted to elucidate the functional roles of newly identified TB-associated genetic loci.