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Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

HIV infection and aging.

José R Blanco1, Ana M Caro, Santiago Pérez-Cachafeiro

  • 1San Pedro-CIBIR Hospital, Logroño, Spain. jrblanco@riojasalud.es

AIDS Reviews
|December 24, 2010
PubMed
Summary
This summary is machine-generated.

Older adults with HIV face diagnostic delays and poorer immune responses to HAART. Further research is needed to optimize treatment regimens for this growing demographic.

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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • The global median age of HIV-infected individuals is rising.
  • Older adults experience unique challenges in HIV diagnosis and management.
  • Age-related factors can mask early HIV symptoms and delay presentation.

Purpose of the Study:

  • To review the impact of aging on HIV infection.
  • To evaluate the response of older patients to highly active antiretroviral therapy (HAART).
  • To identify challenges in managing HIV in the elderly population.

Main Methods:

  • Review of existing literature on HIV in older adults.
  • Analysis of studies comparing HAART response in older versus younger patients.
  • Examination of factors influencing HAART efficacy and safety in the elderly.

Main Results:

  • Older HIV patients present later due to masked symptoms and lower perceived risk.
  • While virologic response to HAART is similar, older adults show poorer immunological and clinical outcomes.
  • Comorbidities and polypharmacy complicate HAART efficacy, safety, and pharmacokinetics/pharmacodynamics.

Conclusions:

  • Older adults with HIV require tailored management strategies.
  • Specific clinical trials are needed to develop optimized HAART regimens for the elderly.
  • Further research should focus on improving HAART efficacy and safety in aging HIV populations.