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Microarray analysis of papillary thyroid cancers in Korean.

Hyun Sook Kim1, Do Hyung Kim, Ji Yeon Kim

  • 1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

The Korean Journal of Internal Medicine
|December 24, 2010
PubMed
Summary

This study analyzed gene expression in Korean papillary thyroid cancer (PTC) and found distinct profiles, including reduced Foxa2 activity, potentially linked to the BRAF V600E mutation.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Papillary thyroid cancer (PTC) is the most common thyroid malignancy.
  • The BRAF V600E mutation is a frequent genetic abnormality in PTC, particularly prevalent in Korean patients.
  • Distinct molecular mechanisms underlie PTC development.

Purpose of the Study:

  • To investigate unique genetic profiles in Korean PTC using cDNA microarray analysis.
  • To identify differentially expressed genes in PTC compared to normal thyroid tissue.
  • To explore the role of BRAF V600E mutations in Korean PTC.

Main Methods:

  • cDNA microarray analysis of five PTC samples and paired normal thyroid tissues.
  • Genotyping for BRAF mutations in PTC samples.
Keywords:
BRAF mutationFOXA2 protein, humanOligonucleotide array sequence analysisThyroid cancer

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  • Validation of gene expression using real-time PCR and immunohistochemistry on 35 PTC patients.

    • Main Results:

    • Four out of five PTC samples analyzed carried the BRAF V600E mutation.
    • Microarray analysis revealed 96 upregulated and 16 downregulated genes in PTC.
    • Real-time PCR confirmed differential expression of key genes, including reduced FOXA2 activity with cytoplasmic accumulation in PTC.

    Conclusions:

    • Korean PTC exhibits specific genetic profiles, with reduced Foxa2 activity and cytoplasmic accumulation.
    • Similarities and differences exist between these findings and previous PTC studies.
    • Further research is required to elucidate the relationship between FOXA2 and BRAF mutations in Korean PTC.