Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supporting Feedback and Trust in CBME: A Conjoint WBA Workshop for Trainers and Trainees.

The clinical teacher·2026
Same author

Nurses' knowledge, attitudes, and role perception in medication administration: do hospital context and nurses' level of professional experience make a difference?

BMC nursing·2025
Same author

A multivariate randomized response model for mixed-type data.

Journal of applied statistics·2025
Same author

Heuristic evaluation and simulated use testing of infusion pumps to inform pump selection.

International journal of medical informatics·2019
Same author

Exploring Hidden In-Hospital Fall Clusters from Incident Reports Using Text Analytics.

Studies in health technology and informatics·2019
Same author

Temporal prediction of in-hospital falls using tensor factorisation.

BMJ innovations·2018
Same journal

From association to causation: interpreting propensity score-based analyses in real-world evidence.

Korean journal of anesthesiology·2026
Same journal

Video laryngeal mask-guided placement of electromyographic endotracheal tubes for intraoperative neuromonitoring during thyroidectomy: a simulator-based feasibility report.

Korean journal of anesthesiology·2026
Same journal

Amino acids for renal protection: time to implement in clinical practice.

Korean journal of anesthesiology·2026
Same journal

Easy DAO2 index: a novel hemodynamic risk factor for predicting mortality in surgical and critically ill patients.

Korean journal of anesthesiology·2026
Same journal

Association of dexmedetomidine with improved survival in ICU delirium.

Korean journal of anesthesiology·2026
Same journal

Cadaveric investigation of an ultrasound-guided obturator canal approach for obturator nerve block.

Korean journal of anesthesiology·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Therapeutic hypothermia.

Hing-Yu So1

  • 1Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Hong Kong.

Korean Journal of Anesthesiology
|December 24, 2010
PubMed
Summary
This summary is machine-generated.

Therapeutic hypothermia (TH) shows promise for post-cardiac arrest patients, but challenges remain in its application and management. Careful monitoring during cooling and rewarming phases is crucial to prevent complications and ensure patient safety.

Keywords:
Cardiac arrestHypothermiaPost-cardiac arrest syndromeTherapeutic hypothermia

More Related Videos

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Related Experiment Videos

Last Updated: Jun 5, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Neurology

Background:

  • Therapeutic hypothermia (TH) has historical roots but faced limitations in early clinical use.
  • Recent studies support moderate TH (32.0-34.0℃) for post-cardiac arrest patients, expanding its application beyond initial indications.
  • Evidence suggests TH may be beneficial even in patients with cardiogenic shock, challenging traditional contraindications.

Purpose of the Study:

  • To review the current understanding and application of therapeutic hypothermia in post-cardiac arrest care.
  • To outline the phases of TH, including induction, maintenance, de-cooling, and normothermia.
  • To highlight key considerations and potential complications associated with TH implementation.

Main Methods:

  • Review of historical data and recent clinical studies on therapeutic hypothermia.
  • Description of the four phases of TH: induction, maintenance, de-cooling, and normothermia.
  • Discussion of methods for temperature control and management of associated physiological changes.

Main Results:

  • TH application has evolved, with widespread use in intensive care units (ICUs) for various post-cardiac arrest scenarios.
  • Precautions during induction include avoiding over-cooling, hypokalemia, hyperglycemia, and shivering.
  • Maintenance of TH involves various methods, requiring attention to pharmacokinetics, hemodynamics, and infection risk; optimal duration is typically 12-24 hours.

Conclusions:

  • Effective TH management requires careful attention to each phase, particularly de-cooling and rewarming, to prevent serious complications like hyperkalemia.
  • Fever management is critical post-TH, with a recommendation for maintaining normothermia for 72 hours.
  • Despite challenges, TH remains a vital intervention in post-cardiac arrest care, with ongoing research addressing its complexities.