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Therapy for Alzheimer's Disease: How Effective are Current Treatments?
Krista L Lanctôt1, Ryan D Rajaram, Nathan Herrmann
1Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada krista.lanctot@sunnybrook.ca.
Abstract:
Available symptomatic therapies for the treatment of Alzheimer's disease (AD) have been based on known neurotransmitter dysfunctions associated with the illness. The second-generation cholinesterase inhibitors and the N-methyl D-aspartate receptor antagonist memantine have been widely prescribed and studied. Meta-analyses of these therapies were reviewed, focusing on effectiveness and tolerability. Although many of the meta-analyses demonstrate statistically significant improvements, some question if these benefits are sufficient to justify their current widespread and protracted use. This has spurred the development of new disease-modifying therapies that aim to have a greater impact on this debilitating illness.
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