Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2025
Same author

AI-driven reclassification of multiple sclerosis progression.

Nature medicine·2025
Same author

Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis.

Immunologic research·2024
Same author

Prognostic factors for worsening and improvement in multiple sclerosis using a multistate model.

Multiple sclerosis (Houndmills, Basingstoke, England)·2024
Same author

Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis.

Neurology·2024
Same author

A review of Bruton's tyrosine kinase inhibitors in multiple sclerosis.

Therapeutic advances in neurological disorders·2024

Related Experiment Video

Updated: Jun 5, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Atacicept: targeting B cells in multiple sclerosis.

Hans-Peter Hartung1, Bernd C Kieseier

  • 1Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

Therapeutic Advances in Neurological Disorders
|December 24, 2010
PubMed
Summary

B cells play a key role in multiple sclerosis (MS) immunopathology. A novel B-cell therapy, atacicept, showed promise but was suspended due to increased inflammatory activity in MS trials.

Keywords:
B cellsB lymphocytesataciceptimmunotherapiesmultiple sclerosistreatment

More Related Videos

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jun 5, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Area of Science:

  • Neuroimmunology
  • Immunology

Background:

  • Multiple sclerosis (MS) was traditionally viewed as T-cell-mediated.
  • Emerging evidence highlights B cell and autoantibody involvement in MS pathogenesis.
  • This provides a rationale for B-cell-targeted therapies in MS.

Purpose of the Study:

  • To review the role of B cells in MS immunopathology.
  • To evaluate the potential of atacicept, a novel B-cell targeted therapy, for MS.

Main Methods:

  • Review of evidence for B cell involvement in MS.
  • Analysis of atacicept's mechanism of action on B cells.
  • Summary of clinical trial data for atacicept in MS.

Main Results:

  • Atacicept selectively targets mature B cells, plasma cells, and late B-cell development stages.
  • Efficacy of atacicept demonstrated in animal models and in rheumatoid arthritis and systemic lupus erythematosus.
  • MS clinical trials were initiated to assess safety, tolerability, and efficacy.

Conclusions:

  • Atacicept trials in MS were unexpectedly suspended due to increased inflammatory activity.
  • Further research is needed to understand the complex role of B cells and targeted therapies in MS.