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[Relationship of Chinese medicine syndrome pattern with heart function and brain natriuretic peptide in patients with

Hui Li1, Shu-Yun Xie, Wei-Xing Lu

  • 1Department of Cardiology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing. lihui8832@163.com

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|December 25, 2010
PubMed

Insights

Chinese medicine syndrome patterns correlate with heart function in heart failure (HF) patients. Left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP) levels can objectively assess HF severity and aid in syndrome differentiation.

Area of Science:

  • Integrative Medicine
  • Cardiology
  • Traditional Chinese Medicine

Background:

  • Heart failure (HF) management benefits from understanding its diverse presentations.
  • Traditional Chinese Medicine (TCM) categorizes HF into distinct syndrome patterns.
  • Objective markers are needed to correlate TCM patterns with Western medical assessments.

Purpose of the Study:

  • To investigate the relationship between TCM syndrome patterns and cardiac function in HF patients.
  • To evaluate ultrasonic cardiography (USCG) parameters and brain natriuretic peptide (BNP) levels as indicators of HF severity within TCM patterns.

Main Methods:

  • 116 HF inpatients were classified into three TCM syndrome groups: qi-yin deficiency (QYD), qi-deficiency and blood-stasis (QDBS), and yang-deficiency with water overflowing (YDWO).
  • USCG parameters (LVEDs, LVEDd, LVEF) and serum BNP levels were measured for all participants.
  • Statistical analysis was performed to determine correlations between TCM patterns and cardiac function markers.

Main Results:

  • Left ventricular ejection fraction (LVEF) decreased and BNP levels increased progressively across the TCM patterns in the order: QYD → QDBS → YDWO (P < 0.01).
  • TCM syndrome patterns showed significant correlations with all USCG parameters and BNP levels.
  • BNP (r = 0.71) and LVEF (r = -0.34) demonstrated particularly strong associations with TCM syndrome patterns (P < 0.05).

Conclusions:

  • LVEF and BNP levels serve as valuable objective and quantitative indices for assessing heart failure severity.
  • These cardiac function markers can effectively aid in the differentiation of TCM syndrome patterns in heart failure patients.
Abstract

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