Related Experiment Video

Updated: Jun 5, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Myocardial perfusion single photon emission computed tomography in asymptomatic diabetics

K Harshad1, I Sathyamurthy, G Ashish

  • 1Department of Nuclear Medicine/Department of Cardiology, Apollo Hospitals, Chennai, Tamil Nadu, India. ismurthy@hotmail.com

Indian Heart Journal
|December 25, 2010
PubMed

Insights

Coronary artery disease (CAD) screening is vital for asymptomatic diabetic patients. Myocardial Perfusion SPECT (MPS) effectively identifies ischemia, aiding risk stratification and long-term follow-up in diabetes mellitus (DM).

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diabetology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality in diabetic patients.
  • Diabetes mellitus (DM)-induced autonomic neuropathy can lead to asymptomatic CAD.
  • Screening for CAD in diabetic individuals is crucial due to the high mortality risk.

Purpose of the Study:

  • To determine the prevalence of asymptomatic CAD in diabetic patients using Myocardial Perfusion SPECT (MPS).
  • To evaluate the efficacy of MPS as a screening tool for identifying ischemia in asymptomatic diabetics.

Main Methods:

  • Prospective study of 88 asymptomatic Type 2 DM patients (age 40-65, duration >5 years).
  • Assessment of risk factors including hypertension, dyslipidemia, smoking, family history, and BMI.
  • All patients underwent a two-day MPS protocol; 38 also had Coronary Angiography (CAG) for significant stenosis (>50%).

Main Results:

  • Abnormal myocardial perfusion detected in 43% of diabetics versus 11% of controls.
  • MPS identified 81 perfusion defects (19 fixed, 62 reversible).
  • CAG revealed significant coronary stenosis in 68.4% of evaluated patients; MPS demonstrated 86.6% sensitivity and 51% specificity compared to CAG.

Conclusions:

  • Myocardial Perfusion SPECT (MPS) is a sensitive diagnostic tool for detecting ischemia in asymptomatic diabetic patients.
  • MPS serves as an effective screening test for risk stratification in diabetes mellitus.
  • MPS holds prognostic value for predicting CAD outcomes and is useful for long-term patient follow-up.
Abstract

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...