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Deep vein thrombosis in protein S deficiency
1Norvic International Hospital, Thapathali, Kathmandu, Nepal. abhashjoshi221@gmail.com
JNMA; Journal of the Nepal Medical Association
|December 25, 2010
Summary
Protein S deficiency, a rare condition affecting blood clotting, can cause deep vein thrombosis (DVT). This case highlights DVT in a 53-year-old male, emphasizing the need for timely diagnosis and management of this anticoagulant protein disorder.
Area of Science:
- Hematology
- Vascular Medicine
- Genetics
Background:
- Protein S is a crucial vitamin K-dependent anticoagulant protein.
- It acts as a cofactor for activated protein C, inhibiting factors Va and VIIIa.
- Protein S deficiency, though rare, increases thrombosis risk.
Observation:
- This case report details a 53-year-old male diagnosed with deep vein thrombosis (DVT).
- The DVT was attributed to a deficiency in Protein S.
- Diagnosis was confirmed via Venous Doppler and free Protein S level measurement (ELISA).
Findings:
- The patient presented with DVT, a serious condition linked to Protein S deficiency.
- Both hereditary and acquired forms of Protein S deficiency can lead to thrombotic events.
- Thrombosis manifestations occur in both heterozygous and homozygous deficiencies.
Implications:
- Early diagnosis and management of Protein S deficiency are vital to prevent severe thrombotic events like DVT, pulmonary embolism, and stroke.
- Long-term anticoagulant therapy is a common treatment for Protein S deficiency.
- This case underscores the importance of considering Protein S deficiency in unexplained thrombosis.
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