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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Videos

Ab interno trabeculectomy.

Mina B Pantcheva1, Malik Y Kahook

  • 1Rocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado Denver, Denver, CO 80045, USA.

Middle East African Journal of Ophthalmology
|December 25, 2010
PubMed
Summary

Trabectome surgery offers a novel approach for glaucoma, potentially avoiding complications like anterior synechiae. However, it may cause IOP spikes and hyphema, and long-term data are still needed.

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Management

Background:

  • Traditional anterior chamber drainage angle surgeries like trabeculotomy and goniotomy have variable long-term success in adults, often due to postoperative anterior synechiae (AS).
  • Congenital glaucoma treatments in children show success rates between 68% and 100%.

Purpose of the Study:

  • To evaluate the ab interno trabeculectomy using the Trabectome™ as a novel surgical approach for glaucoma.
  • To assess the safety and efficacy of Trabectome surgery in preventing AS formation and improving surgical outcomes.

Main Methods:

  • The Trabectome™ procedure involves the selective removal and ablation of the trabecular meshwork and inner wall of Schlemm's canal.
  • Comparison of Trabectome surgery's safety profile (hypotony, infection) with traditional trabeculectomy and glaucoma drainage device implantation.
Keywords:
TrabectomeTrabecular MeshworkTrabeculectomy

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Main Results:

  • Trabectome surgery presents an appealing safety profile regarding early hypotony and infection compared to other procedures.
  • Potential advantages include applicability in regions with limited postoperative follow-up capabilities.
  • However, the procedure is associated with early postoperative intraocular pressure spikes and a high incidence of hyphema, with IOP typically remaining in the mid-teen range.

Conclusions:

  • Trabectome surgery is a promising alternative for glaucoma management, potentially avoiding AS formation.
  • It does not preclude future conjunctival surgeries like trabeculectomy or drainage device implantation.
  • Further randomized, long-term clinical data are required to define its definitive role in the glaucoma surgical armamentarium.