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Updated: Jun 5, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Immunomodulators for all patients with inflammatory bowel disease?
Sandro Ardizzone1, Andrea Cassinotti, Gianpiero Manes
1Head of IBD Unit, Cattedra e Divisione di Gatroenterologia ed Endoscopia Digestiva, Azienda Ospedaliera 'L. Sacco', Polo Universitario, Milano, Italy.
New insights into Crohn
Area of Science:
- Gastroenterology and Immunology
- Inflammatory Bowel Disease Pathophysiology
Background:
- Recent advancements in understanding Crohn's disease (CD) and ulcerative colitis (UC) pathogenesis.
- Progressive shift towards evidence-based treatment strategies grounded in pathophysiology.
Purpose of the Study:
- To review the use of conventional immunomodulators in treating inflammatory bowel disease (IBD).
- To explore critical areas advocating for early and widespread use of these immunomodulatory agents.
Main Methods:
- Review of recommended and suggested uses of conventional immunomodulators.
- Analysis of current literature on azathioprine, 6-mercaptopurine, and methotrexate in IBD treatment.
Main Results:
- Increased understanding of IBD pathophysiology leads to more frequent use of immunomodulators.
- Conventional immunomodulators like azathioprine, 6-mercaptopurine, and methotrexate are key treatment options.
Conclusions:
- A better grasp of IBD pathophysiology supports the use of immunomodulators.
- Early and broader application of conventional immunomodulators in IBD management is warranted in specific contexts.
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