Related Experiment Video
Updated: Jun 5, 2026
Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Sidestream cigarette smoke exposure effects on baroreflex in adult rats
Vitor E Valenti1, Luiz Carlos de Abreu, Celso Ferreira
1Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP) , Rua Napoleão de Barros 715, São Paulo, SP, Brazil. valenti@unifesp.br
Background:
It has been evidenced in the literature that exposure to cigarette smoke causes hypertension in rats; however, it has not been demonstrated if the baroreflex function is impaired before the animal becomes hypertensive.
Objective:
We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in Wistar normotensive rats.
Methods:
Rats were exposed to SSCS during three weeks, 180 minutes, five days per week, at a concentration of monoxide carbon between 100-300 ppm. Mean arterial pressure (MAP) and heart rate (HR) were evaluated through cannulation of the femoral vein and artery.
Results:
There was no significant difference between control and SSCS groups regarding basal mean arterial pressure and heart rate, sympathetic and parasympathetic components of the baroreflex function.
Conclusion:
Our data suggest that three weeks of exposure to SSCS is not enough to significantly impair cardiovascular parameters and baroreflex sensitivity in normotensive Wistar rats.
