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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Published on: September 27, 2018
Significant pathogens in peritonsillar abscesses
T E Klug1, J-J Henriksen, K Fuursted
1Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, NBG, Building 10, Nørrebrogade 44, Aarhus C 8000, Denmark. tejsehlersklug@hotmail.com
Abstract:
Peritonsillar abscesses (PTA) are polymicrobial infections, with a diverse aerobic and anaerobic flora. The aim of the present study is to compare bacteriologic culture results from patients with PTA to those from patients undergoing elective tonsillectomy (clinically non-infected tonsils), to better elucidate the pathogenic significance of various isolates. A prospective study was conducted on 36 PTA patients undergoing acute tonsillectomy and on 80 electively tonsillectomised patients. Fusobacterium necrophorum (FN) and Streptococcus group A (GAS) were isolated significantly more frequently from the tonsillar cores of PTA patients, from both the abscessed (p = 0.001 and p = 0.046, respectively) and non-abscessed sides (p < 0.001 and p = 0.046, respectively), than from the tonsillar cores of electively tonsillectomised patients. Our findings indicate that FN and GAS are the prominent pathogens in PTA. In patients with PTA, the incidence of FN and GAS isolated from the abscessed tonsil was the same as from the non-abscessed contralateral side, and the growth was comparable by a semi-quantitative approach. Our findings suggest that FN is also of pathogenic importance in acute tonsillitis, and that FN growth is not a subsequent phenomenon once an abscess has formed. Our findings further suggest that other factors influence the development of PTA.
Insights
Fusobacterium necrophorum (FN) and Streptococcus group A (GAS) are key pathogens in peritonsillar abscesses (PTA). These bacteria are significantly more prevalent in PTA patients, suggesting their primary role in infection development.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Microbiology
Background:
- Peritonsillar abscesses (PTA) are complex infections involving multiple microorganisms.
- Understanding the specific bacterial culprits in PTA is crucial for effective treatment.
Purpose of the Study:
- To compare bacterial cultures from PTA patients with those from patients undergoing elective tonsillectomy.
- To identify the specific pathogens and elucidate their role in PTA development.
Main Methods:
- Prospective study involving 36 PTA patients and 80 control patients undergoing elective tonsillectomy.
- Bacteriologic cultures were performed on tonsillar cores from both PTA and control groups.
Main Results:
- Fusobacterium necrophorum (FN) and Streptococcus group A (GAS) were isolated significantly more often from PTA patients' tonsillar cores.
- These pathogens were prevalent on both abscessed and non-abscessed sides in PTA patients.
- FN and GAS presence was comparable between abscessed and contralateral tonsils.
Conclusions:
- FN and GAS are identified as prominent pathogens in peritonsillar abscesses.
- FN appears to play a significant role in acute tonsillitis and PTA formation, not just as a secondary invader.
- Additional factors likely contribute to the development of PTA beyond these primary pathogens.
Related Concept Videos
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Brain Abscess l: Introduction
Determinants of Bacterial Pathogenicity and Virulence
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Bacterial Meningitis
Acute Pyelonephritis II: Diagnostic Studies and Management
