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Updated: Jun 5, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
Cell therapy for cardiovascular disease: a comparison of methods of delivery
Nabil Dib1, Harris Khawaja, Samantha Varner
1Mercy Gilbert and Chandler Regional Medical Centers, 3555 S. Val Vista Dr., Gilbert, AZ 85297, USA. ndib@heartsciencescenter.com
Abstract:
The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods of delivery: systemic infusion, intracoronary infusion, transvenous coronary sinus, and intramyocardial. This review discusses the advantages and disadvantages of the delivery approaches above.

