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Updated: Jun 5, 2026

Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
Psychological inflexibility and symptom expression in anorexia nervosa
Rhonda M Merwin1, C Alix Timko, Ashley A Moskovich
1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Abstract:
The purpose of this article is to outline a model of anorexia nervosa (AN) as a disorder of psychological inflexibility, motivated by an insatiable desire for prediction and control with related intolerance for uncertainty. We describe preliminary data that provide initial support for this conceptualization and point to the ways in which mindfulness and acceptance-based strategies might be particularly useful for treating AN. This article is not intended to be an exhaustive literature review, rather a conceptual framework to guide future research and treatment development.
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