Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
Controlled-Potential Coulometry: Electrolytic Methods01:17

Controlled-Potential Coulometry: Electrolytic Methods

Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential ensures...
Potentiometry: Types of Electrodes01:19

Potentiometry: Types of Electrodes

Reference electrodes serve as a stable reference point for potentiometric measurements, while indicator and working electrodes react to variations in the composition of a solution.
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
Controlled-Current Coulometry: Overview01:27

Controlled-Current Coulometry: Overview

Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
Electrodes: Overview01:17

Electrodes: Overview

Electrochemical measurements are conducted in an electrochemical cell composed of various components that control and measure the current and potential. One fundamental component is electrodes, conductive materials that enable electron transfer reactions at their surfaces.
There are two main types of electrodes in electrochemical cells. The first type, known as the working or indicator electrode, has a potential that is sensitive to the analyte's concentration and reacts to changes in the...
Interfacial Electrochemical Methods: Overview01:06

Interfacial Electrochemical Methods: Overview

Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current passing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overcoming Limitations for Ultrasensitive <i>In Situ </i>pH Measurements in Marine Waters while Maintaining Traceability to Primary Standards.

Chimia·2026
Same author

Symmetrical pH Electrochemical Cell Coupled to Constant Potential Coulometry for Improved Sensitivity and Precision: Part 1. Fundamental Considerations.

ACS measurement science au·2026
Same author

Symmetrical pH Electrochemical Cell Coupled to Constant Potential Coulometry for Improved Sensitivity and Precision: Part 2. Submersible Probe for In Situ Measurements.

ACS measurement science au·2026
Same author

Zero-current chronopotentiometry for wired biosensors.

Mikrochimica acta·2025
Same author

Let Us Talk about pH, the Confusing Pillar of Aqueous Systems.

ACS sensors·2025
Same author

Spatially Resolved Ion Sensing by Voltammetric Ion Transfer Microscopy.

JACS Au·2025

Related Experiment Video

Updated: Jun 5, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Membrane response model for ion-selective electrodes operated by controlled-potential thin-layer coulometry.

Eric Bakker1

  • 1Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland.

Analytical Chemistry
|December 25, 2010
PubMed
Summary

Numerical simulations elucidate the behavior of thin-layer coulometric sensors. This research provides a theoretical framework for developing ion-selective chemical sensors that may not require frequent recalibration.

More Related Videos

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
09:18

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique

Published on: May 3, 2015

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
09:18

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique

Published on: May 3, 2015

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Solvent polymeric membranes doped with ionophores are used in ion-selective chemical sensors.
  • Controlled-potential thin-layer coulometry offers a method for sensor operation.
  • Understanding sensor response is crucial for developing reliable analytical tools.

Purpose of the Study:

  • To elucidate the electrochemical response behavior of controlled-potential thin-layer coulometric sensors.
  • To establish a theoretical basis for designing potentially recalibration-free ion-selective chemical sensors.
  • To guide the formulation of membrane materials for optimal sensor performance.

Main Methods:

  • Numerical simulation of electrochemical response.
  • Modeling mass transport by diffusion in bulk phases.
  • Applying ion-selective electrode theory for interfacial ion exchange.

Main Results:

  • Diffusion in the membrane phase can become rate-limiting for traditional ion-selective electrode formulations.
  • This rate-limiting diffusion is advantageous for thin samples (≤20 μm).
  • Simulations provide design guidance for sensors operating at millimolar sample concentrations and address ion interference.

Conclusions:

  • The study provides a theoretical foundation for developing recalibration-free coulometric sensors.
  • Membrane material formulation is critical for achieving desired diffusion characteristics.
  • Enhanced selectivity is required compared to direct potentiometry to mitigate ion interference.