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Related Experiment Videos

Studies on monensin toxicity in goats.

R R Dalvi1, S G Sawant

  • 1Toxicology Laboratory, School of Veterinary Medicine, Tuskegee University, Alabama 36088.

Zentralblatt Fur Veterinarmedizin. Reihe A
|June 1, 1990
PubMed
Summary

High monensin doses (55 ppm) in goats caused liver damage, indicated by anorexia and diarrhea. Lower doses (11 ppm or 8 mg/kg) did not show adverse effects on goat liver health.

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Area of Science:

  • Veterinary medicine
  • Toxicology
  • Animal science

Background:

  • Monensin is an ionophore antibiotic commonly used in livestock.
  • Understanding monensin's toxicological effects is crucial for animal welfare and agricultural practices.
  • Goats are a significant livestock species, and their response to feed additives warrants investigation.

Purpose of the Study:

  • To investigate the potential hepatotoxicity of orally administered monensin in goats.
  • To determine the dose-dependent effects of monensin on goat liver function.
  • To identify safe monensin administration levels for goats.

Main Methods:

  • Goats were administered varying doses of monensin orally.
  • Monensin doses included 55 mg/kg feed (55 ppm) for three weeks, 11 ppm for three weeks, and 8 mg/kg body weight/day for five days.
  • Clinical signs, pentobarbital sleeping time, and serum sorbitol dehydrogenase (SDH) levels were monitored.

Main Results:

  • Goats receiving 55 ppm monensin exhibited anorexia, diarrhea, prolonged pentobarbital sleeping time, and elevated serum SDH.
  • These clinical and biochemical changes suggest monensin-induced hepatotoxicity at the 55 ppm dose.
  • Goats administered lower monensin levels (11 ppm or 8 mg/kg/day) showed no clinical signs or biochemical evidence of liver damage.

Conclusions:

  • Oral administration of monensin at 55 ppm for three weeks can induce hepatotoxicity in goats.
  • Monensin at lower doses (11 ppm or 8 mg/kg/day) appears to be safe for goats regarding liver function.
  • Establishing safe monensin dosage is critical for preventing adverse health effects in goats.

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