Related Experiment Video
Updated: Jun 5, 2026

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
Antimicrobial activity of ruthenium-based intercalators
Albert Bolhuis1, Lorna Hand, Julia E Marshall
1Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 AY, UK. a.bolhuis@bath.ac.uk
Abstract:
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coli, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.
More Related Videos
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Antimicrobial Effectiveness
Inhibitors of Bacterial DNA Synthesis
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Antiprotozoal Agents

