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Updated: Jun 5, 2026
Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
Published on: June 11, 2020
Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities
David P Cormode1, Willem J M Mulder, Zahi A Fayad
1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234 New York, NY 10029, USA.
Abstract:
Pancreatic islet transplantation may provide an effective therapy for patients with type I diabetes. By encapsulating islets in alginate capsules, their survival is substantially improved. Methods to monitor the distribution of the encapsulated islets during delivery and afterward would help to optimize this type of therapy. Barnett and coworkers (1) showed, for the first time, it is possible to visualize encapsulated islets by using magnetic resonance (MR) imaging, computed tomography (CT), and ultrasonography (US) after the inclusion of perfluorocarbon in the capsules. Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice.
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