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[The effectiveness of disinfectants from kinetic viewpoints]
W Hunger1, C Höller, K O Gundermann
1Abteilung Hygiene, Sozialhygiene und Gesundheitswesen im Klinikum, Christian-Albrechts-Universität Kiel.
Zentralblatt Fur Hygiene Und Umweltmedizin = International Journal of Hygiene and Environmental Medicine
|May 1, 1990
Summary
Aldehyde disinfectants were quantitatively evaluated using germ carrier experiments. A kinetic approach simplifies efficiency assessment, showing aldehyde efficacy is concentration and time-independent when disinfectant consumption is negligible.
Area of Science:
- Microbiology
- Disinfection Science
Background:
- Quantitative assessment of instrumental disinfectants is crucial for infection control.
- Aldehyde-based disinfectants are commonly used for medical instruments.
- Understanding disinfectant efficacy under various conditions is essential.
Purpose of the Study:
- To quantitatively evaluate two aldehyde disinfectants using germ carrier experiments.
- To develop and apply a kinetic approach for assessing disinfectant efficiency.
- To investigate the influence of disinfectant concentration and exposure time on germ reduction.
Main Methods:
- Germ carrier experiments using wet/dried cotton and mineralized rubber tubes.
- Testing with Staphylococcus aureus and Pseudomonas aeruginosa.
- Quantitative germ counting before and after exposure using a Spiralmeter.
- Application of a kinetic model (alpha = RF/C0t) to analyze 336 data points.
Main Results:
- A kinetic approach successfully rationalized disinfectant efficiency data.
- Efficacy (alpha) was independent of concentration (C0) and time (t) when disinfectant consumption was negligible.
- Disinfectant consumption at low concentrations on wet carriers caused reduced killing rates, an effect disproven on dry carriers.
Conclusions:
- The kinetic approach provides a simplified method for evaluating aldehyde disinfectant efficacy.
- Disinfectant consumption can impact germ-killing rates, particularly on wet carriers.
- Further research should explore this kinetic model's applicability to suspension experiments and other disinfectant classes.