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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Remarkable postvaccination spatiotemporal changes in United States rotavirus activity
Aaron T Curns1, Catherine A Panozzo, Jacqueline E Tate
1National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. agc8@cdc.gov
The Pediatric Infectious Disease Journal
|December 25, 2010
Summary
Rotavirus activity typically spread from Southwest to Northeast in the US. Following vaccine introduction in 2006, this predictable spatiotemporal pattern was no longer observed in surveillance data.
Area of Science:
- Public Health
- Epidemiology
- Virology
Background:
- Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
- Historically, US rotavirus surveillance data from 1991-2004 showed a distinct annual spatiotemporal pattern, with peak activity beginning in the Southwest and progressing to the Northeast.
- This established pattern provided a benchmark for understanding viral transmission dynamics.
Purpose of the Study:
- To investigate the impact of rotavirus vaccine introduction on the established spatiotemporal patterns of rotavirus activity in the United States.
- To compare the geographic spread of rotavirus before and after the 2006 vaccine introduction.
Main Methods:
- Analysis of US laboratory surveillance data for rotavirus.
- Comparison of spatiotemporal disease patterns during the two years preceding vaccine introduction (2004-2005) with the two years following introduction (2006-2007).
Main Results:
- The typical Southwest to Northeast progression of annual peak rotavirus activity was not observed in the post-vaccine introduction period.
- Surveillance data from 2006-2007 did not replicate the previously documented seasonal spread of rotavirus across the US.
Conclusions:
- Rotavirus vaccine introduction in 2006 altered the traditional spatiotemporal dynamics of rotavirus activity in the US.
- The disappearance of the predictable geographic spread suggests a significant impact of vaccination on rotavirus transmission patterns.
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