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A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review
Anne M Eskes1, Dirk T Ubbink, Maarten J Lubbers
1Department of Quality Assurance & Process Innovation, Room A3-503, Academic Medical Center, University of Amsterdam, Meibergdreef 9, PO Box 22700, Amsterdam 1100 DE, The Netherlands.
World Journal of Surgery
|December 25, 2010
Summary
Hyperbaric oxygen therapy (HBOT) shows promise for healing acute wounds, reducing surgical needs and tissue necrosis. While not universally effective for all acute wound types, it appears beneficial for difficult-to-heal cases.
Area of Science:
- Wound Healing Research
- Hyperbaric Medicine
- Regenerative Medicine
Background:
- Hyperbaric oxygen therapy (HBOT) is a recognized treatment for various wound types.
- The efficacy and safety of HBOT for acute wounds remain incompletely understood.
Purpose of the Study:
- To systematically review randomized controlled trials (RCTs) evaluating HBOT for acute wound healing.
- To assess the impact of HBOT on wound healing and adverse effects compared to other interventions.
Main Methods:
- A systematic review of five relevant databases was conducted up to March 2010.
- Five RCTs involving 360 patients were included.
- Independent assessment of trial selection, quality, data extraction, and synthesis was performed.
Main Results:
- HBOT demonstrated significant benefits in healing crush wounds, reducing surgical procedures, and decreasing tissue necrosis.
- Burn wounds showed quicker healing with HBOT compared to routine care.
- Split skin grafts had a higher percentage of healthy graft area with HBOT, though flap survival in limb defects was not significantly improved.
Conclusions:
- Hyperbaric oxygen therapy (HBOT) appears effective for managing acute, challenging wounds when readily available.
- The findings suggest HBOT can be a valuable adjunct in specific acute wound management scenarios.
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