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Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
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Peptide Bonds

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Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
11:44

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

Peptoid origins.

Ronald N Zuckermann1

  • 1The Molecular Foundry, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA. rnzuckermann@lbl.gov

Biopolymers
|December 25, 2010
PubMed
Summary
This summary is machine-generated.

Peptoid oligomers, synthetic mimics of proteins, accelerate drug discovery and enable new biomaterials. Their versatile synthesis allows exploration of protein-like structures and functions from non-natural polymers.

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

Area of Science:

  • Polymer Chemistry
  • Biotechnology
  • Materials Science

Background:

  • Peptoid oligomers were developed to accelerate drug discovery in biotech and biopharma.
  • Their synthesis, stability, and similarity to polypeptides made them ideal for discovering peptidomimetic drug candidates.
  • Early research demonstrated their potential for identifying high-affinity ligands for pharmaceutical receptors.

Purpose of the Study:

  • To provide an overview of the initial discovery and early developments in peptoid science.
  • To highlight the evolution of peptoid research from drug discovery to materials science.
  • To underscore the significance of peptoids in understanding polymer and protein folding.

Main Methods:

  • Combinatorial library synthesis of short peptoid oligomers.
  • Solid-phase submonomer method for efficient and general peptoid synthesis.
  • Exploration of longer polypeptoid chains for applications in diagnostics, drug delivery, and materials science.

Main Results:

  • Demonstrated discovery of high-affinity ligands using combinatorial peptoid libraries.
  • Development of the peptoid helix and peptoid sheet as secondary-structure mimetics.
  • Established peptoids as valuable tools for creating protein-mimetic materials.

Conclusions:

  • Peptoid synthesis is accessible, driving rapid growth in peptoid science.
  • Peptoids offer insights into the rules governing polymer and protein folding.
  • Peptoids bridge the gap between synthetic polymers and natural protein structure/function.