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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Frequency, risk factors, and effect on long-term survival of increased troponin I following uncomplicated elective

Henry S Loeb1, Jayson C Liu

  • 1Department of Cardiology, Edward Hines Jr. VA Hospital, Hines, Illinois, USA. HSL4134@yahoo.com

Clinical Cardiology
|December 25, 2010
PubMed

Insights

Elevated cardiac troponin I (cTnI) is common after percutaneous coronary intervention (PCI). While multiple stents increase cTnI, long-term survival depends mainly on age and comorbidities, though high cTnI levels also indicate increased risk.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • The clinical significance of elevated cardiac troponin I (cTnI) after uncomplicated percutaneous coronary intervention (PCI) is not well understood.
  • Risk factors and impact on long-term survival require further investigation.

Purpose of the Study:

  • To determine the frequency and predictors of increased cTnI post-PCI.
  • To assess the impact of elevated cTnI on long-term survival.

Main Methods:

  • A study of 907 patients undergoing elective PCI without complications.
  • Exclusion of patients with elevated baseline cTnI or recent myocardial infarction.
  • Measurement of cTnI at least 12 hours post-procedure.

Main Results:

  • Elevated cTnI (above 0.1 ng/ml) occurred in 65.2% of patients, with a mean maximal cTnI (TrMX) of 0.8 ng/ml.
  • The number of deployed stents was the only significant predictor of TrMX (p < 0.0023).
  • Independent predictors of reduced survival included older age, obstructive lung disease, congestive heart failure, and elevated TrMX (p = 0.0272).

Conclusions:

  • Most patients undergoing elective, uncomplicated PCI experience elevated cTnI.
  • Multiple stent deployment is associated with higher cTnI levels.
  • While age and comorbidities are primary survival determinants, the highest post-PCI cTnI values are linked to increased mortality risk.
Abstract

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