Changes on craniofacial structures in children with growth-hormone-deficiency
Ricardo Salas-Flores1, Brian González-Pérez, Ricardo Leopoldo Barajas-Campos
1Hospital General Regional 6, Instituto Mexicano del Seguro Social, Ciudad. Tampico, Tamaulipas, México. risafl@yahoo.com
Revista Medica Del Instituto Mexicano Del Seguro Social
|December 28, 2010
Summary
Children with growth-hormone deficiency (GHD) exhibit distinct craniofacial growth patterns during growth-hormone therapy (GHT). Boys show reduced mandibular length and facial height, while girls present a shortened posterior cranial base and altered maxillo-mandibular relations.
Area of Science:
- Pediatric Endocrinology
- Craniofacial Biology
- Orthodontics
Background:
- Children with growth-hormone deficiency (GHD) often display characteristic craniofacial alterations.
- Understanding these changes is crucial for effective treatment planning during growth-hormone therapy (GHT).
Purpose of the Study:
- To characterize the craniofacial growth patterns in children with GHD undergoing GHT.
- To compare cephalometric measurements between GHD children on GHT and a healthy reference group.
Main Methods:
- A cross-sectional study involving 46 children (14 girls, 32 boys) aged 4-18 years.
- Two groups were analyzed: 23 healthy subjects (reference) and 23 patients with GHD on GHT.
- Cephalograms were compared using independent t-tests.
Main Results:
- Boys with GHD on GHT showed significantly smaller total mandibular length, lower anterior facial height, and total anterior facial height, with a retrognathic facial type.
- Girls with GHD on GHT exhibited a shortened posterior cranial base length, a high mandibular plane angle, and a wide anterior maxillo-mandibular relation compared to controls.
Conclusions:
- Cephalometric analysis reveals specific craniofacial growth differences in GHD children during GHT.
- Considering initial cephalometric morphology is recommended before initiating GHT for optimal outcomes.
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