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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Changes on craniofacial structures in children with growth-hormone-deficiency

Ricardo Salas-Flores1, Brian González-Pérez, Ricardo Leopoldo Barajas-Campos

  • 1Hospital General Regional 6, Instituto Mexicano del Seguro Social, Ciudad. Tampico, Tamaulipas, México. risafl@yahoo.com

Revista Medica Del Instituto Mexicano Del Seguro Social
|December 28, 2010
PubMed

Insights

Children with growth-hormone deficiency (GHD) exhibit distinct craniofacial growth patterns during growth-hormone therapy (GHT). Boys show reduced mandibular length and facial height, while girls present a shortened posterior cranial base and altered maxillo-mandibular relations.

Area of Science:

  • Pediatric Endocrinology
  • Craniofacial Biology
  • Orthodontics

Background:

  • Children with growth-hormone deficiency (GHD) often display characteristic craniofacial alterations.
  • Understanding these changes is crucial for effective treatment planning during growth-hormone therapy (GHT).

Purpose of the Study:

  • To characterize the craniofacial growth patterns in children with GHD undergoing GHT.
  • To compare cephalometric measurements between GHD children on GHT and a healthy reference group.

Main Methods:

  • A cross-sectional study involving 46 children (14 girls, 32 boys) aged 4-18 years.
  • Two groups were analyzed: 23 healthy subjects (reference) and 23 patients with GHD on GHT.
  • Cephalograms were compared using independent t-tests.

Main Results:

  • Boys with GHD on GHT showed significantly smaller total mandibular length, lower anterior facial height, and total anterior facial height, with a retrognathic facial type.
  • Girls with GHD on GHT exhibited a shortened posterior cranial base length, a high mandibular plane angle, and a wide anterior maxillo-mandibular relation compared to controls.

Conclusions:

  • Cephalometric analysis reveals specific craniofacial growth differences in GHD children during GHT.
  • Considering initial cephalometric morphology is recommended before initiating GHT for optimal outcomes.
Abstract

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