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Livedoid vasculopathy as a coagulation disorder
Paulo Ricardo Criado1, Evandro Ararigboia Rivitti, Mirian Nacagami Sotto
1Dermatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. prcriado@uol.com.br
Autoimmunity Reviews
|December 28, 2010
Summary
Livedoid vasculopathy (LV) is a painful skin condition causing leg ulcers and scars. This review analyzes its causes, pathology, and treatment, focusing on thrombophilic states.
Area of Science:
- Dermatology
- Vascular Medicine
- Pathology
Background:
- Livedoid vasculopathy (LV) is a chronic occlusive vascular disease affecting dermal vessels.
- It presents as painful ulcerations on the lower extremities, often leading to atrophie blanche.
- Histopathology typically shows minimal inflammation.
Purpose of the Study:
- To review and analyze existing literature on livedoid vasculopathy.
- To evaluate the etiopathogenic associations, particularly thrombophilia.
- To assess pathological findings and current therapeutic strategies for managing LV.
Main Methods:
- Comprehensive literature search for studies on livedoid vasculopathy.
- Analysis of case reports, clinical studies, and reviews.
- Evaluation of data on disease associations, histopathology, and treatment outcomes.
Main Results:
- LV is strongly associated with thrombophilic states, increasing clotting risk.
- Pathological findings include dermal vessel occlusion and potential thrombosis.
- Management is challenging, with various treatments showing variable efficacy.
Conclusions:
- Understanding the link between LV and thrombophilia is crucial for diagnosis and management.
- Further research is needed to establish optimal therapeutic guidelines.
- Multidisciplinary approaches are often required for effective patient care.
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