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Updated: Jun 5, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave-assisted efficient synthesis of aryl ketone β-C-glycosides from unprotected aldoses
Weiwei Feng1, Zhijie Fang, Jingmei Yang
1School of Chemical Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing 210094, China.
Abstract:
Condensation between unprotected aldoses and dibenzoylmethane catalyzed by NaHCO(3) in the cosolvents EtOH and H(2)O (4:1) under microwave irradiation gave aryl ketone β-C-glycosides 6b-i in higher yields (from 50% with C-riboside 6g up to 99% with C-glucoside 6b) and better anomeric selectivities (β-configuration >95%) in a shorter reaction time (90 min), compared with previous conventional methodologies. This method provides an attractive alternative to the existing means for the preparation of high value ketone β-C-glycosides.
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