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Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: Jun 5, 2026

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions.

Mihaela Žigman¹, Le A Trinh, Scott E Fraser

¹Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2-152, 1100 Fairview Avenue North, Seattle, WA 98109, USA. mihaela.zigman@zoo.uni-heidelberg.de

Current Biology : CB

|December 28, 2010

Summary

This summary is machine-generated.

Coordinated cell division orientation in zebrafish neural progenitors is essential for proper neural tube formation. Scribble protein controls this process, ensuring correct tissue architecture.

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Area of Science:

Developmental Biology
Cell Biology
Zebrafish Model Organisms

Background:

Understanding how single-cell events influence tissue morphogenesis is a key challenge.
The zebrafish neural keel offers a model to study cell division orientation in vivo.

Purpose of the Study:

To investigate the role of single-cell division orientation in neural tube morphogenesis.
To identify molecular mechanisms controlling cell division orientation in neuroepithelial progenitors.

Main Methods:

Utilized zebrafish embryos to observe neural keel progenitor cell division.
Investigated the function of Scribble (Scrib) and N-cadherin in cell division and tissue development.
Analyzed cell-cell adhesion dynamics and cell polarity pathways.

Main Results:

Coordinated progenitor cell division orientation is crucial for forming a single, straight neural tube lumen.
Scribble is required for oriented cell division, independent of known polarity pathways.
Scribble regulates α-catenin foci clustering, influencing cell-cell adhesion and division orientation.
Loss of Scribble or N-cadherin leads to abnormal mitoses and neural tube defects.

Conclusions:

Scribble-dependent cell adhesion clusters guide neuroepithelial progenitor division orientation.
Tissue architecture is determined by oriented cell divisions, with feedback mechanisms ensuring robust morphogenesis.