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Updated: Jun 5, 2026

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

High-throughput mouse phenotyping.

Hilary Gates¹, Ann-Marie Mallon, Steve D M Brown

¹MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0RD, UK.

Methods (San Diego, Calif.)

|December 28, 2010

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Developing standardized phenotyping pipelines, like EMPReSSslim, is crucial for understanding gene function and genetic loci roles. This approach enables robust data collection across diverse mouse genetics centers for comprehensive biological system analysis.

Area of Science:

Genetics and Genomics
Systems Biology
Bioinformatics

Background:

Comprehensive phenotyping is essential for elucidating gene pleiotropy and the broader roles of genetic loci in biological systems.
International efforts are generating vast numbers of mouse mutants, necessitating efficient characterization methods.
Standardized, validated phenotyping platforms are required for robust, large-scale data acquisition across multiple institutions.

Purpose of the Study:

To describe the rationale and methodology of the EMPReSSslim phenotyping pipeline.
To address the challenges in large-scale phenotyping for mouse genetics research.
To facilitate the capture and dissemination of broad-based phenotypic data.

Main Methods:

Development and implementation of the EMPReSSslim phenotyping pipeline.

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Published on: November 11, 2015

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Mouse Eye Enucleation for Remote High-throughput Phenotyping

Published on: November 19, 2011

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

Published on: November 11, 2015

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Incorporation of standardized phenotyping platforms validated across diverse mouse genetics centers.

Capture of diverse data, from biochemical to physiological parameters, across biological systems.

Main Results:

EMPReSSslim captures a broad range of data on diverse biological systems.
Data capture and dissemination are facilitated through defined parameters and ontological descriptions.
Phenotypic data is accessible via the EuroPhenome database for searching biological or clinical phenotypes.

Conclusions:

Standardized phenotyping pipelines are vital for large-scale genetic research.
EMPReSSslim exemplifies a successful approach to broad-based phenotyping challenges.
Accessible data platforms like EuroPhenome are key for leveraging phenotypic information.