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High-throughput analysis of gene expression on tissue sections by in situ hybridization

Gregor Eichele1, Graciana Diez-Roux

  • 1Genes and Behavior Department, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen, Germany. geichel@gwdg.de

Methods (San Diego, Calif.)
|December 28, 2010
PubMed
Abstract

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...