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Effects of peroxisome proliferator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: a
Xiao Huang1, Jiangpei Zhao, Tongfeng Zhao
1College of Life Sciences, Zhejiang University, and Department of GEriatrics, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310000, China.
Objective:
Results from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol.
Methods:
74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis.
Results:
We did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference=0.10, 95% confidence interval (0.02, 0.22), P=0.02, Pheterogeneity=0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference=0.10, 95% confidence interval (-0.00, 0.20), P=0.06, Pheterogeneity=0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD=-0.40, 95% CI (-0.76, -0.05), P=0.02, Pheterogeneity<0.00001, and for analysis excluding the outlier studies: SMD=-0.23, 95% CI (-0.39, -0.06), P=0.006, Pheterogeneity=0.86.
Conclusions:
Our meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians.
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