Related Experiment Video

Updated: Jun 5, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

HCV infection and the incidence of CKD

Adeel A Butt1, Xiaoqiang Wang, Linda F Fried

  • 1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. butta@dom.pitt.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 28, 2010
PubMed

Insights

Hepatitis C virus (HCV) infection increases the risk of developing chronic kidney disease (CKD) and shortens the time to its onset. Targeted monitoring for CKD is recommended for HCV-infected individuals.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • The relationship between Hepatitis C Virus (HCV) infection and the development of Chronic Kidney Disease (CKD) is not fully understood, especially considering traditional risk factors and therapies.
  • Existing research has not clearly defined the risk of incident CKD in HCV-infected individuals.

Purpose of the Study:

  • To investigate the association between HCV infection and the risk of developing incident CKD stages 3-5.
  • To determine if HCV infection influences the time to CKD onset.
  • To explore the impact of traditional CKD risk factors in HCV-infected and uninfected populations.

Main Methods:

  • A national cohort study was conducted using data from the ERCHIVES database.
  • HCV-infected veterans (n=18,002) were compared with HCV-uninfected controls (n=25,137) from 2001-2006.
  • Statistical analyses, including hazard ratios (HR) and Kaplan-Meier curves, were used to assess CKD risk and time to onset.

Main Results:

  • HCV-infected patients exhibited a higher risk of developing CKD stages 3-5 (HR, 1.30; 95% CI, 1.23-1.37).
  • Despite a lower prevalence of diabetes, hypertension, and dyslipidemia, HCV infection was linked to a shorter time to CKD.
  • Decompensated liver disease significantly predicted CKD in both HCV-infected and uninfected groups.

Conclusions:

  • HCV infection is an independent risk factor for CKD development and progression.
  • HCV-infected individuals require focused screening and monitoring for CKD.
  • Further research is needed to address limitations such as lack of proteinuria data and limited representation of women.
Abstract

More Related Videos

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...