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Related Experiment Video

Updated: Jun 5, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Aortitis and periaortitis in ankylosing spondylitis.

Carlo Palazzi¹, Carlo Salvarani, Salvatore D'Angelo

¹Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza and Matera, Italy. kaps57@virgilio.it

Joint Bone Spine

|December 28, 2010

Summary

Ankylosing spondylitis can lead to serious aortic complications like aortitis and periaortitis. Early recognition and treatment of these conditions are crucial for improving patient prognosis.

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Area of Science:

Cardiology
Rheumatology
Vascular Medicine

Background:

Ankylosing spondylitis (AS) is a chronic inflammatory disease.
Aortic involvement, including aortitis and periaortitis, is a serious complication of AS.
These conditions can lead to significant morbidity and mortality if untreated.

Purpose of the Study:

To highlight the potential for aortic complications in ankylosing spondylitis.
To emphasize the importance of recognizing and managing aortitis and periaortitis in AS patients.

Main Methods:

Review of clinical manifestations and pathological findings in AS patients with aortic involvement.
Discussion of diagnostic considerations and treatment strategies for aortitis and periaortitis.

Main Results:

Aortic root inflammation and fibrosis are common, leading to aortic regurgitation.
Conduction system abnormalities, such as atrioventricular blocks, can occur.
Periaortitis can cause compressive effects on adjacent structures, including ureters and vessels.

Conclusions:

Aortitis and periaortitis are significant, potentially life-threatening complications of ankylosing spondylitis.
Physicians must maintain a high index of suspicion for these conditions in AS patients.
Prompt diagnosis and management are essential for improving outcomes.