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Antipsychotic dose and diminished neural modulation: a multi-site fMRI study
1Dept. of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87131, United States. cabbott@salud.unm.edu
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|December 28, 2010
Summary
Antipsychotic medication in schizophrenia patients affects neural networks, particularly motor and default mode networks. Higher doses and typical antipsychotics show diminished activation and modulation in these networks.
Area of Science:
- Neuroimaging
- Psychiatry
- Schizophrenia Research
Background:
- The impact of antipsychotics on brain activity in schizophrenia is not well understood.
- Functional magnetic resonance imaging (fMRI) is used to study brain function.
Purpose of the Study:
- To investigate how antipsychotic medication influences neural networks during a motor task in schizophrenia patients.
- To analyze data from a large, multi-site fMRI study.
Main Methods:
- Utilized functional magnetic resonance imaging (fMRI) on 79 medicated schizophrenia patients and 114 controls.
- Applied independent component analysis (ICA) to identify neural networks.
- Regressed ICA time courses with experimental design and analyzed group differences and correlations with chlorpromazine equivalents.
Main Results:
- Significant group differences were observed in motor, default mode, and attentional networks.
- Chlorpromazine equivalents correlated with motor and default mode networks.
- Typical antipsychotics showed less positive modulation in motor/caudate networks compared to atypical antipsychotics.
Conclusions:
- Antipsychotic dosage appears to reduce neural activation in motor and default mode networks in schizophrenia.
- Typical antipsychotics may decrease positive modulation in subcortical motor networks.
- Antipsychotics represent a potential confounding factor in fMRI studies of schizophrenia.
